Minggu, 28 Desember 2014

DIET & GENERAL INTEGRATIVE ONCOLOGY


Natural Health Products and Cancer Treatment, Hal Gunn, Complementary Corner, Summer 2003 Vol. 4 No. 3 www.abreastinthewest.ca   (BCCA policy re: natural agents)

Multivitamin Use and Breast Cancer Incidence in a Prospective Cohort of Swedish Women, Laarson, Akesson, Bergkvist & Wolk,  Am. J. Clin. Nutr. 2010; 91 (5): 1268-1272.

Use of Complementary / Integrative Nutritional Therapies During Cancer Treatment: Implications in Clinical Practice,  Kumar et al.,  Canc. Control  2002; 9 (3): 236-243.

Complementary Therapies for Cancer-related Symptoms, Deng, Cassileth & Yeung, J. Support Oncol. 2004; 2: 419-429.

Complementary and Alternative Therapies for Cancer, Cassileth & Deng, Oncologist 2004; 9: 80-89.

Integrative Oncology: Complementary Therapies in Cancer Care, Cassileth, Heitzer & Gubili, Cancer Chemother. Rev. 2008; 3 (4): 204-211.

Lifestyle changes and the ‘spontaneous’ regression of cancer: An initial computer analysis  Foster, Int. J. Biosoc. Res., 1988; 10 (1): 17-33.

Exercise in Prevention and Management of Cancer, Newton & Galvao, Curr. Treat. Opt. Oncol. 2008; 92 (3): 135-146.

Forgiveness Can Improve Immune Function, Owen, Soc. Behav. Med. 32nd Annual Meeting and Scientific Sessions: Abstract 4010. Presented April 30, 2011.
Molecular Targets of Dietary Agents for Prevention and Therapy of Cancer, Aggarwal & Shishodia, Biochem. Pharmacol. 2006; 71: (10): 1397-1421.
Analysis of Botanicals and Dietary Supplements for Antioxidant Capacity: a Review,  Prior & Cao,  J. AOAC Int. 2000; 83 (4): 950-956.

(Gamma)ɣ-Tocopherol Traps Mutagenic Electrophiles Such As NOx and Complements (Alpha)α-Tocopherol: Physiological Implications, Christen, Woodall, Shigenaga, et al., Proc. Natl. Acad. Sci. 1997; 94: 3217-3222.

Dietary Fat, Fiber, Vegetable, and Micronutrients are Associated with Overall Survival in Postmenopausal Women Diagnosed with Breast Cancer, McEligot, Largent, Ziogas, Peel & Anton-Culver,  Nutr. Cancer. 2006; 55 (2): 132-140.

Dietary Influences on Survival After Ovarian Cancer, Nagle, Purdie, Webb, et al., Int. J. Cancer 2003; 106 (2): 264-269.

Association of Dietary Patterns with Cancer Recurrence and Survival in Patients with Stage III Colon Cancer, Meyerhardt , Niedzwiecki , Hollis, et al., J. Amer. Med. Assoc.  2007; 298 (7):754 -764.
Greater Survival After Breast Cancer in Physically Active Women with High Vegetable-Fruit Intake Regardless of Obesity, Pierce, Stefanick, Flatt, et al., J. Clin. Oncol. 2007; 25 (17): 2345-2351.

Influence of a Diet Very High in Vegetables, Fruit and Fiber and Low in Fat on Prognosis Following Treatment for Breast Cancer, J. Amer. Med. Assoc. 2007; 298 (3): 289-298.

Baseline Nutritional Status is Predictive of Response to Treatment and Survival in Patients treated by Definitive Chemo-Radiotherapy for a Locally Advanced Esophageal Cancer, Di Fiore, Lecleire, Pop, et al., Am. J. Gastroenterol. 2007; 102 (11): 2557-2563.
Is Voluntary Vitamin and Mineral Supplementation Associated with Better Outcome in Non-Small Cell Lung Cancer Patients? Results from the Mayo Clinic Lung Cancer Cohort. Jatoi, Williams, Nichols, et al.,   Lung Cancer. 2005; 49 (1): 77-84.

Cancer and Natural Medicine – a Textbook of Basic Science and Clinical Research , John Boik, 1996 Oregon Medical Press.

Naturally There’s Hope – A Handbook for the Naturopathic Care of Cancer Patients, McKinney, Trafford Press, 2003.

Survival Impact of Integrative Cancer Care in Advanced Metastatic Breast Cancer,  Block, Gyllenhaal, Tripathy, et al., In press, The Breast Journal 2009; 15 (4).

Survival Impact of Integrative Care in Advanced Prostate Cancer, Block, Gyllenhaal, Chodak, et al., Proc. Am. Soc. Clin. Oncol. 2003; 22: abstract 1746.

Mind-body Therapies for the Management of Pain, Astin, Clin. J. Pain 2004; 20 (1): 27-32.

Pilot Crossover Trial of Reiki vs. Rest for Treating Cancer-related Fatigue, Tsang, Carlson & Olson, Integr. Cancer Ther. 2007; 6 (1): 25-35.

Efficacy of Homeopathic Therapy in Cancer Treatment,  Milazzo, Russell & Ernst,  Eur. J. Cancer, 2006; 42 : 282-289.

Effect of Homeopathic Medicines on Transplanted Tumors in Mice, Sunila, Kuttan, Preethi & Kuttan, Asian Pac. J. Cancer Prev. 2007; 8: 390-394.

Series of Case Reports: Clinical Evaluation of a Complex Homeopathic Injection Therapy in the Management of Pain in Patients After Breast Cancer Treatment, Orellana, Ruiz de Viñaspre & Kaszkin-Bettag, Altern. Ther. Health Med. 2010; 16 (1): 54-59.
Cytotoxic Effects of Ultra-diluted Remedies on Breast Cancer Cells, Frenkel, Mishra, Sen, et al.,  Int. J. Oncol. 2010; 36 (2): 395-403.  PMID: 20043074
The Effect of Thiamine Supplementation on Tumour Proliferation: A Metabolic Control Analysis Study,
ComõÂn-Anduix, Boren, Martinez, et al., Eur. J. Biochem. 2001; 268: 4177- 4182.

The Hoxsey Treatment: Cancer Quackery or Effective Physiological Adjuvant?, Brinker,  J. Naturopathic Med. 1996; 6(1): 9-23.

Broad in vitro Efficacy of Plant-derived Betulinic Acid Against Cell Lines Derived from the Most Prevalent Human Cancer Types, Kessler, Mullauer, dee Roo & Medema, Cancer Lett. 2007; 251 (1): 132-145                                                               

Complementary & Alternative Medicine, Larson, Trustee Mag. 2006, Sept.

Survival Impact of Integrative Care in Advanced Prostate Cancer, Block, Gyllenhaal, Chodak et al.,  Proc. Am Soc Clin Oncol. 2003; 22: abstract 1746.

Survival Impact of Integrative Cancer Care in Advanced Metastatic Breast Cancer, Block, Gyllenhaal, Tripathy et al., The Breast Journal. 2008; in press.

Natural Compounds in Cancer Therapy – Promising Non-toxic Anti-tumor Agents from Plants and Other Natural Sources, John Boik, Oregon Medical Press  2001.

An Alternative Medicine Definitive Guide to Cancer, Diamond, Cowden & Goldberg, Future Medicine Publishing, 1997.

Genetic Program Linking Cancer to Hemostasis Identified, Boccaccio, et al., Nature 2005; 434: 396-400.

Metastasis: A Therapeutic Target for Cancer, Steeg & Theodorescu, Nat. Clin. Pract. Oncol. 2008; 5 (4): 206-219.
Effect of Gamma-Linolenic Acid on the Transcritional Activity of the Her-2/neu (erbB-2) Oncogene, Menendez, Vellon, Colomer & Lupu, J. Natl. Cancer Inst. 2005; 97 (2): 1611-1615.

Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction, Meijerman, Bejnen and Schellens, Oncologist 2006; 11: 742-752.

Energy-modulating Vitamins – A New Combinatorial Therapy Prevents Cancer Cachexia in Rat Mammary Carcinoma, Perumai, Shanthi & Sachdanandam, Br. J. Nutr. 2005; 93(6): 901-909.

P13 Kinase /Akt Pathway as a Therapeutic Target in Multiple Myeloma, Harvey & Lonial, Future Oncol. 2007; 3(6): 639-647.

Starvation-dependent Differential Stress Resistance Protects Normal but Not Cancer Cells Against High-dose Chemotherapy, Raffaghello, Lee, Sadfie, et al., Proc Natl Acad Sci USA  2008; 105 (24): 8215-8220.
Targeting Energy Metabolism in Brain Cancer Through Calorie Restriction and the Ketogenic Diet,  Seyfried, Kiebish, Marsh & Mukherjee,  J. Can. Res. Ther. 2009; 5: 7-15.  PMID: 20009300

Bringing Evidence to Complementary and Alternative Medicine in Children with Cancer: Focus on Nutrition-related Therapies, Kelly,  Pediatr. Blood Cancer 2008; 50 (2 Suppl): 490-493; discussion 498.


Adherence to Mediterranean Diet and Health Status: Meta-analysis, Sofe, Cesari, Abbate, et al., BMJ 2008; 337: a1344.

Early Hormonal Data from a Multicentre Phase II Trial Using Transdermal Oestrogen Patches as a First-line Hormonal Therapy in Patients with Locally Advanced or Metastatic Prostate Cancer, Langley, Godsland, Kynastn, et al., BJU Int.  2008; 102 (4): 442-445.

Dietary Alpha-, Beta-, Gamma- and Delta-Tocopherols in Lung Cancer Risk, Mahabir, Schendel, Dong, et al., Int. J. Cancer 2008; 123: 1173-1180.

Allergic Pulmonary Inflammation Promotes the Recruitment of Circulating Tumor Cells to the Lung, Taranova, Maldonado, Vachon, et al., Cancer Res.  2008; 68 (20): 8582-8589.

Interaction of  Warfarin with Drugs, Natural Substances, and Foods, Greenblatt & von Moltke, J. Clin. Pharmacol. 2005; 45 (2): 127-132.

Intensive Lifestyle Changes May Affect the Progression of Prostate Cancer, Ornish, Weidner, Fair, et al., J Urol. 2005; 174 (3): 1065-1069.

High Casein-Lactalbumin Diet Accelerates Blood Coagulation in Rats, Chan, Lou & Hargrove, J. Nutr. 1993; 123 (6): 1010-1016.

Therapeutic Applications of Whey Protein, Marshall, Altern. Med. Rev. 2004; 9 (2): 136-156.

Dairy Products, Calcium, and Vitamin D and Risk of Prostate Cancer, Chan & Giovannucci, Epidemiol. Rev. 2001; 23 (1): 87-92.

Lycopene and Apo-12- Lycopenal Reduce Cell Proliferation and Alter Cell Cycle Progression in Human Prostate Cancer Cells, Ford, Elsen, Zuniga, et al., Nutr. Cancer 2011; 63 (2): 256–263.

Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial,  Brasky, Till, White,et al., Am. J. Epidemiol. 2011;  doi: 10.1093/aje/kwr027

Testosterone Therapy in Men With Untreated Prostate Cancer, Morgentaler, Lipshultz, Bennett, et al., J. Urol. 2011; 185 (4): 1256-1260.

Radical Prostatectomy Versus Watchful Waiting in Early Prostate Cancer, Bill-Axelson, Holmberg,
Ruutu, et al., N. Engl. J. Med. 2011; 364: 1708-1717, 1770-1772.
A High Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids is Associated with Increased Risk of Prostate Cancer, Williams, Whitley, Hoyod, et al., Nutr. Res. 31 2011; 31: 1–8.

Dairy Products and Breast Cancer: the IGF-I, Estrogen, and bGH Hypothesis, Outwater, Nicholson & Barnard, Med. Hypotheses 1997; 48 (6): 453-461.

Prospective Study of Grapefruit Intake and Risk of Breast Cancer in Postmenopausal Women: the Multi-ethnic Cohort Study, Monroe, Murphy, Kolonel & Pike, Br. J. Cancer 2007; 697 (3): 440-445.

Does Grapefruit Juice Increase the Bioavailability of Orally Administered Sex Steroids? Fingerová, Oborná, Petrová, et al., Ceska Gynekol. 2003; 68 (2): 117-121.

Gamma-linolenic Acid Therapy of Human Glioma- A Review of in vitro, in vivo, and Clinical Studies, Das,  Med. Sci. Monit. 2007; 13 (7): RA119-131.

Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty AcidKapoor & Huang, Curr. Pharm. Biotechnol. 2006; 7(6): 531-534.

Non-linear Dynamics for Clinicians: Chaos Theory, Fractals, and Complexity at the Bedside, Goldberger, Lancet 1996; 347: 1312–1314.

Megadose Vitamins in Bladder Cancer: A Double-blind Clinical Trial, Lamm, Riggs, Shriver et al.,  J. Urol. 1994; 151 (1): 21-26
Health Implications of Mediterranean Diets in Light of Contemporary Knowledge:  Meat, Wine, Fats, and Oils, Kushi, Lenart & Willett, Am. J. Clin. Nutr. 1995; 61 (6Suppl): 1416S-1427S.
Adherence to the Mediterranean Diet Attenuates Inflammation and Coagulation Process in Healthy Adults: The ATTICA Study, Chrysohoou, Panagiotakos, Pitsavos, et al., J. Am. Coll. Cardiol. 2004; 44 (1): 152-158.
Fibrinogen: A Novel Predictor of Responsiveness in Metastatic Melanoma Patients Treated with Bio-chemotherapy: IMI (Italian Melanoma Inter-group) Trial, Guida, Ravaioli, Sileni, et al., J. Transl. Med. 2003; 1 (1): 13. 

Analysis of Botanicals and Dietary Supplements for Antioxidant Capacity: A Review, Prior, Cao, Prior &  Cao,   J. AOAC Int. 2000; 83 (4): 950-956.

Selenium for Preventing Cancer, Dennert, Zwahlen, Brinkman, et al., Cochrane Database of Systematic Reviews 2011, 5: CD005195. DOI: 10.1002/14651858.CD005195.pub2

Seronea repens (Permixon, Saw Palmetto)Inhibits the 5-alpha-reductase Activity of Human Prostate Cancer Cell Lines Without Interfering with PSA Expression, Habib, Ross, Ho, et al., Int. J. Cancer 2005; 114 (2); 190-194.

Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment, Pelosof & Gerber, Mayo Clin. Proc. 2010; 85 (9): 838-854.

The Tumor Lysis Syndrome, Howard, Jones, & Pui, N. Engl. J. Med. 2011; 364: 1844-1854.

Impact of Stress and Mast Cells on Brain Metastases, Theoharides, Rozniecki , Sahagian, et al.,  J. Neuroimmunol. 2008; 205 (1-2): 1-7.
Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer, Chabot, Tsai, Fine, et al., J. Clin. Oncol. 2009 Aug 17. [Epub ahead of print] PMID 19687327.

Berberine and Berberine-containing Plants as Antineoplastic Agents, Tang, Feng, Wang, et al., J. Ethnopharmacol. 2009; 128: 5-17.

Inhibitory Effects of Berberine on the Activation and Cell Cycle Progression of Human Peripheral Lymphocytes, Cell. Mol. Immunol. Xu, Liu & He, 2005; 2 (4): 295-300.

Association Between Coffee Drinking and K-ras Mutations in Exocrine Pancreatic Cancer, Porta, Malats, Guarner, et al., J Epidem. Comm. Health 1999; 53: 702–709
Increased Rates of Chromosome Breakage in BRCA1 Carriers are Normalized by Oral Selenium Supplementation, Kowalska, Narod, Huzarski, et al., Cancer Epidem. Biomark. & Prev. 2005; 14 (5): 1302-1306.
A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy, Nakagawa, Kollmeyer, Morlan, et.al., PLoS ONE 2008; 3 (5): e2318. Epub 2008 May 28.
Perioperative  Arginine-Supplemented Nutrition in Malnourished Patients with Head and Neck Cancer Improves Long-term Survival,  Buijs, van Leeuwen, et al,  Amer. J. Clin. Nutr.  2010;  [Epub ahead of print] September 29, 2010, doi:10.3945/ajcn.2010.29532

Acetyl-L-Carnitine Monograph, Alt. Med. Rev. 2010; 15 (1): 76-83.
Dietary Vitamin K Intake in Relation to Cancer Incidence and Mortality: Results from the Heidelberg Cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), Nimptsch, Rohrmann, Kaaks & Linseisen, Am. J. Clin. Nutr. 2010; 91 (5): 1348-1358. Comment in: Am. J. Clin. Nutr. 2010; 92 (6): 1533-1534; author reply 1534-1535.
Choline. A Nutrient that is Involved in the Regulation of Cell Proliferation, Cell Death, and Cell Transformation, Zeisel,  Adv. Exp. Med. Biol. 1996; 399: 131-141.

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation, Ho, Leung, Hsu, et al. Cancer Res. 2011; 71: 4484-4493.

Forgiveness Can Improve Immune Function, Owen, Soc. Behav. Med. 32nd Annual Meeting and Scientific Sessions: Abstract 4010. Presented April 30, 2011.

Selenium for Preventing Cancer, Dennert, Zwahlen, Brinkman, et al., Cochrane Database of Systematic Reviews 2011, 5: CD005195. DOI: 10.1002/14651858.CD005195.pub2




Ginger for Chemotherapy-related Nausea in Cancer Patients: A URCC CCOP Randomized, Double-blind, Placebo-controlled Clinical Trial of 644 Cancer Patients, Ryan, Heckler, Dakhil et al., J. Clin. Oncol.  2009: 27: 15s, (suppl; abstr 9511 -  2009 ASCO Annual Meeting).

Phase II Trial of Encapsulated Ginger as a Treatment for Chemotherapy-induced Nausea and Vomiting, Zick, Ruffin, Lee et al., Support Care Cancer 2009; 17 (5): 563-572.

A Phase II/III Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Ginger (Zingiber officinale) for Nausea Caused by Chemotherapy for Cancer: A Currently Accruing URCC CCOP Cancer Control Study,  Hickok, Roscoe, Morrow & Ryan,  Support. Cancer Ther. 2007; 4 (4): 247-250.

Protein and Ginger for the Treatment of Chemotherapy-induced Delayed Nausea, Levine, Gillis, Koch et al., J. Altern. Complement. Med. 2008; 14 (5): 545-551.

Antiemetic Effect of Ginger in Gynecologic Oncology Patients Receiving Cisplatin. Manusirivithaya, Sripramote, Tangjitgamol et al., Int. J. Gynecol. Cancer 2004; 14 (6): 1063-1069.

Anti-Emetic Effect of Ginger Powder Versus Placebo as an Add-on Therapy in Children and Young Adults Receiving High Emetogenic Chemotherapy, Pillai, Sharma, Gupta & Bakhshi, Pediatr. Blood Cancer 2011; 56 (2): 234-238.




Oligomeric Proanthocyanidin Complexes: History, Structure & Phytopharmaceutical Applications, A. M. Fine.   Alt. Med Rev. 2000; Vol. 5, No. 2: 144-151. 

Cellular Protection with Proanthocyanidins Derived from Grape Seeds,  Bagchi, Bagchi & Stohs, et al, Ann. N. Y. Acad. Sci.  2002; 957: 260-270. 

Oligomeric Proanthocyanidins ( OPCs) – Monograph,  Alt. Med. Rev. 2003; Vol. 8, No.4: 442-450.

Chemoprevention of Colorectal Cancer by Grapeseed Proanthocyanidin is Accompanied by a Decrease in Proliferation and Increase in Apoptosis,   Nomoto, Iigo, Hamada, et al. Nutr. & Cancer. 2004; Vol. 49, No. 1: 81-89.

Alcohol and Polyphenolic Grape Extract Inhibit Platelet Adhesion in Flowing Blood, de Lange, Scholman, Kraaijenhagen, et al., Eur. J. Clin. Invest. 2004; 4 (12): 818-824.

Red Wine and Red Wine Polyphenolic Compounds But Not Alcohol Inhibit ADP-induced Platelet Aggregation, de Lange, van Golden, Scholman, et al., Eur. J. Intern. Med. 2003; 14 (6): 361-366.

Grape Seed and Skin Extracts Inhibit Platelet Function and Release of Reactive Oxygen Intermediates, Vitseva, Varghese, Chakrabarti, et al., J. Cardiovasc. Pharmacol. 2005; 46 (4): 445-451.

Proanthocyanidin from Grape Seeds Enhances Anti-tumor Effect of Doxorubicin Both in vitro & in vivo, Zhang, Bai, Wu, et al, Pharmazie, 2005; 60: 533-538.

Grape Seed Proanthocyanidin Extract Induced Mitochondria-associated Apoptosis in Human Acute Myeloid Leukaemia 14.3D10 Cells, Hong & Qin,  Chin. Med. J. 2006; 119 (5): 417-421.

Grapeseed Extract Induces Apoptotic Death of Human Prostate Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of Mitochondrial membrane Potential and Cytochrome C Release, Agarwal, Singh & Agarwal, Carcinogenesis 2002; 23 (11): 1869-1876.

Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds, Eng, Ye, Williams, et al., Cancer Res. 2003; 63 (23): 8516-8522.

Grapeseed Extract is an Aromatase Inhibitor and a Suppressor of Aromatase Expression,  Kijima, Phung, Hur, et al., Cancer Res. 2006; 66 (11): 5960-5967.

Grapeseed Extract Inhibits Advanced Human Prostate Cancer Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding Protein 3, Singh, Tyagi, Dhanalakshmi, et al., Int. J. Cancer 2004; 108 (5): 733-740. 

Grape Seed Extract Induces Anoikis and Caspase-mediated Apoptosis in Human Prostate Carcinoma LNCaP Cells: Possible Role of Ataxia Telangiectasis Mutated-p53 Activation, Kaur, Agarwal & Agarwal, Mol. Cancer Ther. 2006; 5 (5): 1265-1274.

Grape Seed Proanthocyanidin Extract Induced Mitochondria-associated Apoptosis in Human Acute Myeloid Leukaemia 14.3D10 cells, Hu & Qin, Chin. Med. J. 2006; 119 (5): 417-421.

Proanthocyanidins from Grape Seeds Inhibit Expression of Matrix Metalloproteinases in Human Prostate Carcinoma Cells, Which is Associated with the Inhibition of Activation of MAPK and NF kappa B, Vayalil, Carcinogenesis 2004; 25 (6): 987-985.

Grape Seed Extract Inhibits Advanced Human Prostate Tumor Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding Protein-3, Singh, Tyagi, Dhanalakshmi,    et al., Int. J. Cancer 2004; 108 (5): 733-740.

Grape Seed Extract Induces Apoptotic Death of Human Prostate Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of Mitochondrial Membrane Potential and Cytochrome C Release, Agarwal, Singh & Agarwal, Carcinogenesis 2002; 23 (11): 1869-1876.

Inhibition of NF-kappaB Pathway in Grape Seed Extract-induced Apoptotic Death of Human Prostate Carcinoma DU145 Cells, Dhanalakshmi, Agarwal & Agarwal, Int. J. Oncol. 2003; 23 (3): 721-727.

Grape Seed Extract Inhibits EGF-induced and Constituitively Active Mitogenic Signallng but Activated JNK in Human Prostate Carcinoma DU145 Cells: Possible Role in Antiproliferation and Apoptosis, Tyagi, Agarwal & Agarwal, Oncogene 2003; 22 (9): 1302-1316.

Matrix Metalloproteinases in Cancer Metastasis: Molecular Targets for Prostate Cancer Prevention by Green Tea Polyphenols and Grape Seed Proanthocyanidins, Katiyar, Endocr. Metabol. Immune Disord. Drug Targets, 2006; 6 (1): 17-24.

Anti-cancer Activity of Grape and Grape Skin Extracts Alone and Combined with Green Tea Infusions, Morré & Morré, Cancer Lett. 2006; 238 (2): 202-209.

Grape Seed Extract Inhibits EGF-induced and Constitutively Active Mitogenic Signaling But Activates JNK in Human Prostate Carcinoma DU145 Cells: Possible Role in Anti-proliferation and Apoptosis, Tyagi, Agarwal & Agarwal, Oncogene 2003; 22 (9): 1302-1316.

Grape Seed Extract Inhibits in vitro and in vivo Growth of Human Colorectal Carcinoma Cells, Kaur, Singh, Gu, et al., Clin. Cancer Res. 2006; 12 (20 Pt 1): 6194-6202.

Proanthocyanidin from Grape Seeds Inactivates the PI3-kinase/PKB Pathway and Induces Apoptosis in a Colon Cancer Cell Line, Engelbrecht, Mattheyse, Ellis, et al., Cancer Lett. 2007; 258 (1): 144-153.

Anti-angiogenic Efficacy of Grape Seed Extract in Endothelial Cells, Agarwal, Singh, Dhanalakshmi & Agarwal, Oncol. Rep. 2004; 11 (3): 681-685.

Experimental Model for Treating Pulmonary Metastatic Melanoma Using Grape-seed Extract, Red wine and Ethanol, Martínez Conesa, Vicente Ortega, et al., Clin. Transl. Oncol. 2005; 7 (3): 115-121.

Grapeseed Extract Inhibits Angiogenesis via Suppression of the Vascular Endothelial Growth Factor Receptor Signaling Pathway, Wen, Lu, Zhang & Chen, Cancer Prev. Res. 2008; 1 (7): 554-561

Grapeseed Extract Inhibits VEGF Expression via Reducing HIF-1 alpha Protein Expression, Lu, Zhang, Chen & Wen, Carcinogenesis 2009; 30 (4): 636-644.

Free Radicals and Grape Seed Proanthocyanidin Extract: Importance in Human Health and Disease Prevention, Bagchi, Bagchi, Stohs, et al., Toxicol. 2000; 148 (2-3): 187-197.

Chemoprevention of Colorectal Cancer by Grape Seed Proanthocyanidin is Accompanied by a Decrease in Proliferation and Increase in Apoptosis, Nomoto, Hiroshi, Iigo, et al., Nutr. & Cancer 2004; 49 (1): 81-89.

Synergistic Anti-cancer Effects of Grapeseed Extract and Conventional Cytotoxic Agent Doxorubicin Against Human Breast Carcinoma Cells, Sharma, Tyagi, Singh, et al., Breast Cancer Res. Treat. 2004; 85 (1): 1-12.

Chemopreventative Effects of Grape Seed Proanthocyanidin Extract on Chang Liver Cells, Joshi, Kuszynski, Bagchi & Bagchi, Toxicol. 2000; 155: 83-90.

Gallic Acid, an Active Constituent of Grapeseed Extract, Exhibits Anti-proliferative, Por-apoptotic and Anti-tumorigenic Effects Against Prostate Carcinoma Xenograft Growth in Nude Mice, Kaur, Velmurugan, Rajamanickam, et al., Pharm. Res. 2009; June 20 [Epub ahead of print]  PMID: 19543955.

Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins,  Hou, Fujii, Terahara &Yoshimoto,  Biomed. Biotechnol. 2004; 2004 (5): 321-325.

Signal Transduction Pathways: Targets for Chemoprevention of Skin Cancer, Bode, Lancet Oncol. 2000; 1: 181-188.

Dermal Wound Healing Properties of Redox-active Grape Seed Proanthocyanidins, Khanna, Venojarvi, Roy, et al., Free Rad. Biol. Med. 2002; 33: 1089.

The Cytotoxic Effects of a Novel Grape Seed Proanthocyanidin Extrct on Cultured Human Cancer Cells, Joshi, Ye, Liu, et al., Sci. Proc. 89th Ann. Meet. Amer. Assoc. Cancer Res. 1998, Vol. 39.

Anti-thrombotic Effect of Proanthocyanidin, a Purified Ingredient of Grape Seed, Sano, Oda, Yamashita, et al., Thromb. Res. 2005; 115: 115-121.

Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs Via Activation of c-Jun NH2-Terminal Kinase, Gao, Budhraja, Cheng , et al., Clin. Cancer Res. 2009; 15 (1): 140-149.

Effect of Concord Grape Juice on Chemotherapy-induced Nausea and Vomiting: Results of a Pilot Study, Ingersoll, Wasilewski, Haller, et al., Oncol. Nurs. Forum 2010; 37 (2): 213-221. 
Synergic Effect of Grape Seed Extract with Amphotericin B against Disseminated Candidiasis Due to Candida albicans,  Han,  Phytomedicine, 2007; 14:733–738. http://dx.doi.org/10.1016/j.phymed.2007.08.004
Antibacterial and Antioxidant Activities of Grape (Vitis vinifera) Seed Extracts, Jayaprakasha, Selvi, & Sakariah, Food Res. Intern. 2003; 36:117–122.
Relation Between Intake of Flavonoids and Risk for Coronary Heart Disease in Male Health Professionals, Rimm, Katan, Ascherio, et al., Ann.Intern. Med. 1996; 125: 384–389.
Antiulcer Activity of Grape Seed Extract and Procyanidins, Saito, Hosoyama, Ariga, et al., J. Agri. Food Chem. 1998; 46: 1460–1464.
 Grape Seed Extract Inhibits Advanced Human Prostate Tumor Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding Protein-3, Singh, Tyagi, Dhanalakshmi, Agarwal, & Agarwal, C. Int. J. Cancer  2004; 108: 733–740.
Grapeseed Proanthocyanidin  Extract Induced Mitochondria-Associated Apoptosis in Human Acute Myeloid Leukemia 14.3D10 Cells, Hu & Qin, Chin. Med. J. (Engl.) 2006; 119 (5): 417-421.
Pycnogenol as an Adjunct in the Management of Childhood Asthma, Lau, Riesen, Truong, et al., J. Asthma 2004; 41 (8): 825-832.

Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies, Aggarwal, Bhardwaj, Aggarwal, et al., Anticancer Res. 2004; 24 (5A): 2783-2840.

Resveratrol-induced Apoptosis in Human Breast Cancer Cells is Mediated Primarily Through the Caspase-3-dependent Pathway, Alkhalaf, El-Mowafy, Renno , et al., Arch. Med. Res. 2008; 39 (2): 162-168.  

Resveratrol Inhibits Proliferation, Induces Apoptosis, and Overcomes Chemo-resistance Through Down-regulation of STAT3 and Nuclear factor-kappaB-regulated Anti-apoptotic and Cell Survival Gene Products in Human Multiple Myeloma Cells, Bhardwaj, Sethi, Vadhan-Raj, et al., Blood 2007; 109 (6): 2293-2302.

Resveratrol Induces the Suppression of Tumor-derived CD4+CD25+ Regulatory T Cells,  Yang, Paik, Cho, et al., Int. Immunopharmacol. 2008; 8 (4): 542-547.

Resveratrol Induces Apoptosis and Differentiation in Acute Pro-myelocytic Leukemia (NB4) Cells, Cao, Wang, Liu, et al., J. Asian Nat. Prod. Res. 2005; 7 (4): 633-641. 

Resveratrol: A Candidate Nutritional Substance for Prostate Cancer Prevention, Stewart, Artime & O'Brian, J. Nutr. 2003; 133 (7 Suppl): 2440S-2443S.  
Resveratrol Inhibits Aggregation of Platelets from High-risk Cardiac Patients with Aspirin Resistance, Stef, Csiszar, Lerea, et al., J. Cardiovasc. Pharmacol. 2006; 48 (2): 1-5.
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Involvement of p21WAF1/Cip1, pRB, Bax and NF-kappaB in Induction of Growth Arrest and Apoptosis by Resveratrol in Human Lung Carcinoma A549 cells, Kim, Lee, Choi, et al., Int. J. Oncol. 2003; 23 (4): 1143-1149. 

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Resveratrol and N-AcetylCysteine Block the Cancer-Initiating Step in MCF-10F Cells, Zahid, Saeed, Beseler, et al, Free Radic. Biol. 2010; Epub Oct 7. Med.<http://www.ncbi.nlm.nih.gov/pubmed/20934508?dopt=Abstract>

N-Acetyl-Cysteine, Reactive Oxygen Species and Beyond, Sun, Cancer Biol. Ther. 2010; 9 (2): 109–110.

Mechanisms of Resveratrol-Induced Platelet Apoptosis, Lin, Hsiao, Shih, et al., Cardiovasc. Res. 2009; 83 (3): 575-585.

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