Minggu, 28 Desember 2014

High-Dose Vitamin C Selectively Kills Cancer Cells, Levine, et al., Proc. Natl. Acad. Sciences USA, 2005; 102: 13604-13609.



Vitamin C Deficiency in Cancer Patients, Mayland,Bennett & Allan, Palliat. Med. 2005; 19: 17-20.

High-Dose Vitamin C Selectively Kills Cancer Cells, Levine, et al., Proc. Natl. Acad. Sciences USA, 2005; 102: 13604-13609.

High-dose vitamin C Therapy: Renewed Hope or False Promise?Assouline & Miller, Can. Med. Assoc. J. 2006; 174: 956–957.

Intravenous Ascorbate as a Tumor Cytotoxic Chemotheraeutic Agent, Riordan, et al., Med. Hypotheses 1995; 44: 207-213.

Prolonged Survival linked to Intravenous Vitamin C Seen in Three Cancer Patients, Levine, et al, Can. Med. Assoc. J., 2006; 174: 937-942.

Changes of Terminal Cancer Patients’ Health-related Quality of Life After High Dose Vitamin C Administration, Yeom, Jung & Song, J. Korean Med Sci  2007; 22 (1): 7-11.

Intravenously Administered Vitamin C as a Cancer Therapy: Three Cases, Padayatty, Riordan, Hewitt, et al., CMAJ  2006; 174 (7): 937-942.

A Pilot Clinical Study of Continuous Intravenous Ascorbate in Terminal Cancer Patients, Riordan, Casciari, Gonzalez, et al., P R Health Sci J  2005; 24 (4): 269-276.

Innovation vs. Quality Control: An ‘Unpublishable’Clinical Trial of Supplemental Ascorbate in Incurable Cancer, Cameron & Campbell, Med Hypotheses 1991; 36 (3): 185-189.

Reticulum Cell Sarcoma: Two Complete ‘Spontaneous’ Regressions, in Response to High-dose Ascorbic Acid Therapy.  A Report on Subsequent Progress,  Campbell, Jack & Cameron, Oncology 1991; 48 (6): 495-497.

Changes of Terminal Cancer Patients’ Health-related Quality of Life After High Dose Vitamin C Administration, Yeom, Jung & Song, J. Korean Med Sci  2007; 22 (1): 7-11.

Supplemental Ascorbate in the Supportive Treatment of Cancer: Prolongation of Survival Times in Terminal Human Cancer, Cameron & Pauling,  Proc. Natl Acad Sci USA 1976; 73 (10): 3685-3689.

Supplemental Ascorbate in the Supportive Treatment of Cancer: Reevaluation of Prolongation of Survival Tmes in Terminal Human Cancer, Cameron & Pauling, Proc Natl Acad Sci USA 1978; 75: 4538–4542.

Vitamin C Inhibits p53-induced Replicative Senescence Through Suppression of ROS Production and p38 MAPK Activity, Kim, Jin, Lee, et al., Biochem Pharmacol. 2008; 22 (5): 651-655.

Pharmacological Doses of Ascorbate Act as a Pro-oxidant and Decrease Growth of Aggressive Tumor Xenografts in Mice, Chen, Espey, Sun, et al., Proc. Natl. Acad. Sci. USA  2008; 1105: 11105-11109.

Pharmacologic Ascorbic Acid Concentrations Selectively Kill Cancer Cells: Action as a Pro-drug to Deliver Hydrogen Peroxide to Tissues, Chen, Espey, Krishna, et al., Proc. Natl. Acad. Sci. U S A 2005; 102 (38): 13604-13609.

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use, Padayatty, Sun, Wang, et al., Ann. Intern. Med. 2004; 140 (7): 533-537.

 Ascorbate in Pharmacologic Concentrations Selectively Generates Ascorbate Radical and Hydrogen Peroxide in Extracellular Fluid in vivo, Chen, Espey, Sun, et al., Proc. Natl. Acad. Sci U S A 2007; 104 (21): 8749-8754.

Phase I Clinical Trial of I.V. Ascorbic Acid in Advanced Malignancy, Hoffer, Levine, Assouline, et al., Ann. Oncol. 2008; [Epub ahead of print]

Emerging Role of Ascorbic Acid in the Management of Advanced Breast Carcinoma as a Chemosensitizer, Goel, Agarwal, Mandal, et al., Asian J. Surg. 1999; 22: 333-336.

In vivo Effect of Ascorbic Acid on Enhancement of Human Natural Killer Cell Activity,  Vojdani & Ghoneum,  Nutr. Res.1993; 13: 753-754.
Enhancement of Human Natural Killer Cytotoxic Activity by Vitamin C in Pure and Augmented Formulations, Vojdani & Namatalla, J. Nutr. Environ. Med. 1997; 7 (3): 187-195.
The Orthomolecular Treatment of Cancer II. Clinical Trial of High-dose Ascorbic Acid Supplements in Advanced Human Cancer, Cameron & Campbell,  Chem. Biol. Interact. 1974; 9: 285–315.

Mega-dose Vitamin C as Therapy for Human Cancer?  Borst, Proc Natl Acad Sci USA; 2008; 105: E95.

Vitamin C and Cancer Revisited, Frei & Lawson, Proc Natl Acad Sci USA 2008;105: 11037–11038.

 The Antioxidant Ascorbic Acid Mobilizes Nuclear Copper Leading to a Prooxidant Breakage of Cellular DNA: Implications for Chemotherapeutic Action Against Cancer, Ullah, Khan, Zubair, et al., Cancer Chemother. Pharmacol. 2010 March 6 [Epub ahead of print] PMID: 20213077.

Catalytic Therapy of Cancer by Ascorbic Acid Involves Redox Cycling  of Exogenous/Endogenous Copper Ions and Generation of Reactive Oxygen Species,  Hadi, Ullah, Shamim, Bhatt & Azmi,  Chemotherapy 2010; 56 (4): 280-284.

H(2)O(2)-Mediated Cytotoxicity of Pharmacologic Ascorbate Concentrations to Neuroblastoma Cells:Potential Role of Lactate and Ferritin, Deubzer, Mayer, Kuçi et al., Cell Physiol. Biochem. 2010; 25 (6): 767-774.

New Developments and Novel Therapeutic Perspectives for Vitamin C, Li & Schellhorn, J. Nutr. 2007; 137: 2171-2184.

The Vitamin C: Vitamin K3 System – Enhancers and Inhibitors of the Anti-Cancer Effect, Lamson, Gu, Plaza, et al., Alt. Med. Rev. 2010; December – pre-publication.

Sodium Ascorbate Induces Apoptosis in Neuroblastoma Cell Lines by Interfering with Iron Uptake, Carosio, Zuccari, Orienti, et al., Mol. Cancer 2007; 6 (1): 55-65.





Heterodimeric DNA Binding by the Vitamin D Receptor and Retinoid X Receptors Is Enhanced by 1,25-Dihydroxyvitamin D3 and Inhibited by 9-cis-Retinoic Acid; Evidence for Allosteric Receptor Interactions, Thompson, Jurutka, Haussler, et al., J. Biol. Chem. 1998; 273 (14): 8483–8491.

All-trans Retinoic Acid Antagonizes the Action of Calciferol and Its Active Metabolite, 1,25-Dihydroxycholecalciferol, in Rats, Rohde & DeLuca, J. Nutr. 2005; 135: 1647–1652.

Vitamin D and Cancer, Ali & Vaidya, J. Cancer Res. Ther. 2007; 3 (4): 225-230.

Vitamin D Signalling Pathways in Cancer: Potential for Anti-cancer Therapeutics, Deeb, Trump & Johnson, Nat. Rev. Cancer 2007; 7 (9): 684-700.

Induction of Ovarian Cancer Cell Apoptosis by 1,25-dihydroxy-Vitamin D3 Through the Down-regulation of Telomerase, Jiang, Bao , Li, et al., Biol. Chem. 2004; 279 (51): 53213-53221.

High Vitamin D Levels Linked to Improved Lung Cancer Survival,  Zhou, et al., J. Clin. Oncol. 2007; 25: 479-485.

Vitamin D and Calcium Supplementation Reduces Cancer Risk: Results of a Randomized Trial,  Lappe, et al., Am. J. Clin. Nutr. 2007; 85 (6): 1586-1591.

Vitamin D Supplementation and Total Mortality: a Meta-analysis of Randomized Controlled Trials, Autier and Gandini, Arch. Intern. Med. 2007; 167 (16): 1730-1737.

Do Sunlight and Vitamin D Reduce the Likelihood of Colon Cancer?, Garland & Garland, Int. J. Epidemiol. 2006; 35 (2): 217-220.

Circulating 25-hydroxy Vitamin D Levels and Survival in Patients with Colorectal Cancer, Ng, Meyerhardt, Wu, et al., J Clin Oncol  2008; 26 (18): 2937-2939.

Molecular Basis of Potential of Vitamin D to Prevent Cancer, Ingraham, Bragdon & Nohe, Curr. Med. Res. & Opin. 2008; 241: 139-149.

1{alpha}, 25-Dihydroxyvitamin D3 Potentiates Cisplatin Anti-tumor Activity by p73 Induction in a Squamous Cell Carcinoma Model, Ma, et al., Mol. Cancer Ther. 2008; 7 (9): 3047-3055

Association Between Serum 25(OH)D and Death from Prostate Cancer, Tretli, Hernes, Berg, et al., Br. J. Cancer 2009; 1003: 450-454.

Chemotherapy is Linked to Severe Vitamin D Deficiency in Patients with Colorectal Cancer, Fakih, Trump, Johnson, et al., Int. J. Colorectal Dis. 2009; 242: 219-224.

Dairy Products, Calcium, and Vitamin D and Risk of Prostate Cancer, Chan & Giovannucci, Epidemiol. Rev. 2001; 23 (1): 87-92.

Vitamin D is Associated with Improved Survival in Early-stage Non-Small Cell Lung Cancer Patients, Zhou, Suk, Liu, et al., Cancer Epidemiol. Biomarkers Prev. 2005; 14 (10): 2303-2309.

Vitamin D Analogue EB1089-induced Prostate Regression is Associated with Increased Gene Expression of Insulin-like Growth Factor Binding Proteins, Nickerson T. Huynh H.   J. Endocrinol. 1999; 160 (2): 223-229.

Inhibition of Insulin-like Growth Factor I Receptor Signaling by the Vitamin D Analogue EB1089 in MCF-7 Breast Cancer Cells: A Role for Insulin-like Growth Factor Binding Proteins,  Rozen & Pollak, Int. J. Oncol.  1999; 15 (3): 589-594.

A Combined Pretreatment of 1,25-Dihydroxyvitamin D3 and SodiumValproate Enhances the Damaging Effect of Ionizing Radiation on Prostate Cancer Cells, Gavrilov Leibovich, Ariad, Lavrenkov & Shany,  J. Steroid Biochem. Mol. Biol. 2010 [Epub ahead of print] PMID: 20214985.

Vitamin D3 Distribution and Status in the Body, Heaney, Horst, Cullen & Armas, J. Am. Coll. Nutr. 2009; 28 (3): 252-256.

Vitamin D for Cancer Prevention: Global Pespective, Garland, Gorham, Mohr & Garland, Ann. Epidemiol. 2009; 19 (7): 468-483.

Meta-analysis: Longitudinal Studies of Serum Vitamin D and Colorectal Cancer Risk, Yin, Grandi, Raum, et al., Aliment. Pharmacol. Ther. 2009; 30 (2): 113-125.

Double-blinded Randomized Study of High-dose Calcitriol Plus Docetaxol Compared with Placebo Plus Docetaxol in Androgen-indpendent Prostate Cancer: A Report from the ASCENT Investigators, Beer, Ryan, Venner, et al., J. Clin. Oncol. 2007; 25 (6): 669-674.

A Phase II Trial of Calcitriol and Naproxen in Recurrent Prostate Cancer, Srinvias & Feldman, Anticancer Res. 2009; 29 (9): 3605-3610.

Phase II Trial of High-dose Intermittent Calcitriol (1,25 dihydroxyvitamin D3) and Dexamethasone in Androgen-independent Prostate Cancer, Trump, Potter, Muindi, et al., Cancer 2006; 106 (10): 2136-2142.

Immunomodulatory Effects of Vitamin D: Implications for GVHD, Rosenblatt, Bissonnette, Ahmad, et al., Bone Marr.Transplant. 2010;45 (9): 1463-1468
Vitamin D Status is Associated with Disease-Free Survival and Overall Survival Time in Patients with Squamous Cell Carcinoma of the Upper Aerodigestive Tract, Gugatschka, Kiesler, Obermayer-Pietsch, et al., Eur. Arch. Otorhinolaryngol. 2011 Jan 8. [Epub ahead of print] PMID: 21221617

Seasonal Variation in Blood Drug Concentrations and a Potential Relationship to Vitamin D, Lindh, Andersson, Eliasson & Bjorkhem-Bergman, Drug Metab. Dispos. 2011; Feb. 24 [Epub ahead of Print].

Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma, Drake, Maurer, Link, et al., J. Clin. Oncol. 2010; 28 (27): 4191-4198.





The Anticancer Effects of Vitamin K, Lamson & Plaza, Alt. Med. Rev. 2003; 8 (3): 303-318.

The Mechanisms of Vitamin K2- induced Apoptosis of Myeloma Cells, Tsujioka, Miura, otsuki, et al.,  Haematologica 2006, 91 (5): 613-619.

Oxidative Stress by Ascorbate (Vit C) / Menadione (K3) Association Kills K562 Human Chronic Myelogenous Leukemia Cells and Inhibits its Tumor Growth in Nude Mice, Verrax, Stockis, Tison, et al,  Biochem. Pharmacol. 72 (6): 671-680.

Vitamin K2 Inhibits the Growth and Invasiveness of Hepatocellular Carcinoma Cells Via Protein Kinase A Activation, Otsuka, Kato, Shao, et al., Hepatology 2004; 40 (1): 243-251.

Phase I Trial of Menadiol Diphosphate (Vitamin K3) in Advanced Malignancy, Lim, et al., Invest. New Drugs  2005; 23: 235–239.

The Vitamin C:Vitamin K3 System – Enhancers and Inhibitors of the Anticancer Effect, Lamson, Gu, Plaza, et al., Alt Med. Rev. 2010; 15 (4): 345-351.

Cell Cycle Arrest and Autoschizis in a Human Bladder Carcinoma Cell Line Following Vitamin C and Vitamin K3 Treatment, Jamison, Gilloteaux, Nassiri, et al., Biochem. Pharmacol. 2004; 67 (2): 337-351.




CANCER AND NATURAL MEDICINE

The Paleolithic Prescription – A Program of Diet and Exercise and a Design for Living, Eaton, Shostak, and Konner, 1988.

Dietary Options for Cancer Survivors – A Guide to Research on Foods, Food Substances, Herbals and Dietary Regimens That Might Influence Cancer, Weldon, et al,  American Institute for Cancer Research,  2002.

Stopping Cancer Before It Starts – The American Institute for Cancer Research’s Program for Cancer Prevention, The American Institute for Cancer Research, 1999.
Guns, Germs and Steel – the Fates of Human Societies, Jared Diamond, 1997.
Foods That Fight Cancer, Preventing Cancer by Diet, Richard Beliveau and Denis Gingras, 2007
Cooking with Foods That Fight Cancer, Richard Beliveau and Denis Gingras, 2007

The Complete Natural Medicine Guide to Breast Cancer – A Practical Manual for Understanding, Prevention and Care, Sat Dharam Kaur, ND  2003.

Life Over Cancer, Keith Block, 2009.

Healing the Planet- One Patient at a Time, A Primer in Environmental Medicine, Jozef Krop, 2000.

Healing with Whole Foods - Asian Traditions and Modern Nutrition, Paul Pritchard, 2003.

The Whole Life Nutrition Cookbook – Whole foods recipes for personal and planetary health, 2nd edition, Segersten and Malterre, 2008; Whole Life Press.

Our Toxic World – A Wake-up Call - Chemicals damage your body, brain, behaviour and sex, Doris Rapp, 2004.

Toxic Deception - How the chemicals industry manipulates science, bends the law and endangers your health, Dan Fagin, Marianne Lavelle

The CancerSmart Consumer Guide- How to eliminate toxins from your home and garden products and how to make healthy choices for your family and the environment, Labour Environmental Alliance Society, Vancouver, B.C., www.leas.ca

Clinical Purification, A Complete Treatment and Reference Manual, Gina Nick, 2001, Longevity Through Prevention.

Clinical Oncology, American Cancer Society, 2000

Cancer Medicine 7 : Holland,Frei et al., editors, 7th edition, BC Decker, 2006.

The Biology of Cancer, R. Weinberg, Garland Science, 2007.

Robbins Pathologic Basis of Disease, Sixth edition, R. Cotran,  V. Kumar, & T. Collins, W.B. Saunders Company

Cancer & Natural Medicine - a Textbook of Basic Science and Clinical Research, John Boik, 1996, Oregon Medical Press

Natural Compounds in Cancer Therapy – Promising Non-toxic Anti-tumor Agents from Plants and Other Natural Sources, John Boik, 2001, Oregon Medical Press.

How to Prevent and Treat Cancer with Natural Medicine, Murray, Birdsall, Pizzorno & Reilly, Riverhead Books, 2002.

Naturally There’s Hope – A Handbook for the Naturopathic Care of Cancer Patients,
McKinney, Trafford Press, 2003.

An Alternative Medicine Definitive Guide to Cancer, Diamond, Cowden & Goldberg, Future Medicine Publishing, 1997.

You Don’t Have to Die, Harry Hoxsey, N.D., 1956, Milestone Books

The Cancer Industry -Unravelling the Politics, Ralph W. Moss, 1989, Paragon

A Family Guide - Coping with Chemotherapy Using Homeopathy, Laura Fenton, 2003, Health Harmony Books.


INTEGRATED HEALING
An Introduction to Integrated Healing - Participants’ guide to self-care, healthful nutrition, vitamins, supplements, complementary medical therapies and healing, Center for Integrated Healing, 1998

Third Opinion: An International Directory to Alternative Therapy Centres for the Treatment and Prevention of Cancer and Other Degenerative Diseases, Second edition, J. M. Fink, 1992; Avery Publishing Group.

A Guide to Unconventional Cancer Therapies, Ontario Breast Cancer Information Exchange Project, 1994

Breast Cancer - What you should know (but may not be told) about prevention, diagnosis and treatment, Steve Austin, N.D. and Cathy Hitchcock, M.S.W., 1994, Prima Health Publishing

Breast Cancer - The Complete Guide, Third edition, Yashar Hirshaut & Peter Pressman, 2000, Bantam Books.

Breast Cancer - A Nutritional Approach, Carlton Fredericks, Ph.D., 1977, Grosset & Dunlap

Beating Cancer with Nutrition, Patrick Quillan, 1994, Nutrition times Press.

Secrets to Great Health, Jonn Matsen, N.D., 2001, Prima Publishing

The Schwarzbein Principle, Diana Schwarzbein, MD, 1999, Health Communications

A Holistic Approach to Cancer Therapy, Wolfgang Woeppel, 1995, Pascoe

Love, Medicine & Miracles - Lessons learned about self-healing from a surgeon’s experience with exceptional patients, Bernie. S. Siegel, M.D., 1986, Harper & Row

Homeopathic Medical Repetory, Robin Murphy, N.D., 1993; Hahnemann Academy of North America.

The Cancer Epidemic: Shadow of the Conquest of Nature, Gotthard Booth, 1974, Edwin Mellen Press

Cancer Therapy - the Independent Consumer’s Guide to Non-toxic Treatment and Prevention, Ralph Moss, Equinox Press.

Healthy Fats For Life - Preventing and treating common health problems with essential fatty acids, L. Vanderhaege, K. Karst, 2003, Quarry Health Books

Cancer and Vitamin C, Ewan Cameron & Linus Pauling, 1979, Linus Pauling Institute of Science and Medicine

Cancer as a Turning Point, Lawrence LeShan, 1994, Penguin Press

Nutritional Management of Cancer Patients, Abby S. Block, 1980, Aspen Publishers

Everyone’s Guide to Cancer Therapy, M. Dollinger, E. Rosebaum, & G. Cable, 1997, Andrews-McMeel Publishers

The Wheatgrass Book, Ann Wigmore, ‘Doctor of Natural Laws’, 1985, Avery Publishing Group.
Healing Words – The Power of Prayer and the Practice of Medicine, Larry Dossey 1993.

Head First – The Biology of Hope, Norman Cousins, 1989.

Cancer Principles and Practices, V. DeVita, S. Hellman,& S. Rosenberg, 1997,  Lipincott-Raven Publishers

Handbook of Cancer Chemotherapy, Roland T. Skeel, 2011, Lipincott.

Manual of Clinical Oncology, D. Casciato & B. Lowitz, 1991, Little Brown

Primer of Epidemiology, Gary Friedman, 1980, McGraw-Hill

Foundations of Epidemiology, A. Lilienfeld, 1976, Oxford U. Press

FDA Supplement Warnings - Misleading, Exaggerated or Unproven, Zoltan Rona, June/July 1998, Health Naturally

Increasing and Improving Research in Complementary and Alternative Medicine, Carlo Calabrese, 2000, NIH Office of Alternative Medicine.

The Cancer Blackout - A history of denied and suppressed remedies, Maurice Natenberg, 1959, Regent House.

The Medical Mafia - How to get out of it alive and take back our health & wealth, Ghislaine Lanctot, 2002
edition, self-published.

Hard to Swallow – The Truth About Food Additives, Sargeant and Evans, 1995, Alive Books

Fight for Your Health, Byron Richards, 2006, Walter Publishing.

Cancer - A Healing Crisis - the whole-body approach to cancer therapy, Jack Tropp, 1980, Exposition Press.

The Healing of Cancer - The cures, the cover-ups and the solution now, Barry Lynes, 1989, Marcus Books.

The Tao of Medicine, Stephen Fulder, 1982, Destiny Books.

Cancer Treatment with Fu Zheng Pei Ben Principle, Pan Mingji, et al, 1992,  Fujian Science & Technology Publishing House.

7-Day Detox Miracle  2nd ed.,, Bennett & Barrie , 2001; Three Rivers Press.

Living Downstream: An Ecologist Looks at Cancer and the Environment, Steingraber, 1997, published by Addison-Wesley.

 Dismantling Cancer, Contreras, Baroso-Arnanda & Kennedy, 2004; Interpacific Press.

·        Cancer
·        Nutrition & Cancer
·        Journal of Clinical Oncology
·        Journal of the National Cancer Institute
·        Cancer Research
·        Integrative Cancer Therapies
·        American Journal of Clinical Nutrition
·        Alternative Medicine Review
·        International Journal of Cancer
·        Clinical Pearls
·        Anticancer Research
·        Townsend Letter for Doctors & Their Patients


·        www.oncanp.org
·        www.aicr.org
·        www.lifeovercancer.com
·        www.cancerfacts.com
·        www.nci.nih.gov
·        www.cancer.org      American Cancer Society  1-800-ACS-2345
·        www.cdc.gov.org/cancer
·        www.bccancer.bc.ca
·        www.y-me.org
·        www.asco.org
·        www.Medscape.com  - oncology database
·        www.inspirehealth.ca
·        www.denvernaturopathic.com
·        www.camresearch.net
·        www.ncbi.nlm.nih.gov/PubMed/ 
·        www.oncologystat.com 
·        www.epec.net
·        www.lifeovercancer.com




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