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MUSHROOMS (Reishi, button mushrooms, etc.) Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus), Chen, Oh, Phung, et al., Cancer Res.  2006; 66 (24): 12026-12034. White Button Mushroom Phytochemicals Inhibit Aromatase Activity and Breast Cancer Cell Proliferation, Grube, Eng, Kao, et al., J. Nutr. 2001; 131 (12): 3288-3293. Novel Antioxidant Peptides from Fermented Mushroom Ganoderma lucidum, Sun, He & Xie,  J. Agric. Food Chem. 2004; 52 (21): 6646-6652. Ganodermic Acid T from Ganoderma lucidum Mycelia induces Mitochondria Mediated Apoptosis in Lung Cancer Cells, Tang, Liu, Zhao, et al., Life Sci. 2006; 80 (3): 205-211. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by Ganoderma lucidum and Duchesnea chrysantha extracts, Kim, Kim, Son & Kim, Cancer Lett. 2007; 246 (1-2): 210-217. Coriolus versicolor (Yunzhi) Extract Attenuates Growth of Human Leukemia Xenografts and Induces Apoptosis Through the Mitochondrial Pathway, Zhang, Soboloff, Zhu & Berger, Mol. Pharmacol. 2006; 16 (3): 609-616. Ganoderma lucidum Inhibits Proliferation of Human Breast Cancer Cells by Down-regulation of Estrogen Receptor and NF-kappaB Signalling, Jiang, Slivova & Sliva, Int. J. Oncol. 2006; 29 (3): 695-703. Androgen Receptor-Dependent and -Independent Mechanisms Mediate Ganoderma lucidum Activities in LNCaP Prostate Cancer Cells, Zaidman, Wasser, Nevo & Mahajna, Int. J. Oncol. 2007; 31 (4): 959-967. Effects of Water-soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer, Gao, Tang, Dai, et al., J. Med. Food 2005; 8 (2): 159-168. Effects of Ganopoly (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-stage Cancer Patients, Gao, Zhou, Jiang, et al., Immunol. Invest. 2003; 32 (3): 201-215. Combined Effect of Green Tea and Ganoderma lucidum on Invasive Behaviour of Breast Cancer Cells, Thyagarajan, Zhu & Sliva, Int. J. Oncol. 2007; 30 (4): 963-969. Telomerase-associated Apoptotic Events by Mushroom Ganoderma lucidum on Pre-malignant Human Urothelial Cells, Yuen, Gohel & Au, Nutr. Cancer 2008; 60 (1): 109-119. Dietary Intakes of Mushrooms and Green Tea Combine to Reduce the Risk of Breast Cancer in Chinese Women, Zhng, Huang, Xie & Holman, Int. J. Cancer  2009; 1246: 1404-1408. Ganoderma lucidum (Reishi) in Cancer Treatment, Sliva, Integr. Cancer Ther. 2003; 2 (4): 358-364. The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment,  Kidd, Altern. Med. Rev. 2000; 5(1): 4-27. Anticancer Effects of Ganoderma lucidum: A Review of Scientific Evidence, Yuen & Gohel Nutr. Cancer 2005; 53 (1): 11-17  Natural Killer Cell Activity and Quality of Life Were Improved by Consumption of a Mushroom Extract, Agaricus blazei Murill Kyowa, in Gynecological Cancer Patients Undergoing Chemotherapy, Ahn, Kim, Chae, et al., Int. J. Gynecol. Cancer 2004; 14 (4): 589-594. Secretion of TNF-alpha, IL-8 and Nitric Oxide by Macrophages Activated with Agaricus blazei Murill Fractions in vitro, Sorimachi, Akimoto, Ikehara, et al., Cell Struct. Funct. 2001; 26 (2): 103-108. Characterization and Immuno-modulating Activities of Polysaccharide from Lentinus edodes, Zheng, Jie, Hanchuan & Moucheng, Int. Immunopharmacol. 2005; 5 (5): 811-820. Effects of Ganopoly (a Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-stage Cancer Patients, Gao, Zhou, Jiang, et al., Immunol. Invest. 2003; 32 (3): 201-215. Protective Effects of Ganoderma lucidum Polysaccharides Peptide on Injury of Macrophages Induced by Reactive Oxygen Species, You & Lin, Acta Pharmacol. 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Supplements for Immune Enhancement in Hematological Malignancies, Sze & Chan, Hematology 2009; 313-319. Ganoderma lucidum Inhibits Proliferation of Human Breast Cancer Cells by Down-Regulation of Estrogen Receptor and Nf-kappaB Signalling, Jiang, Slivova & Sliva, Int. J. Oncol. 2006; 29: 695-703. Ganoderic Acids Suppress Growth  and Invasive Behaviour of Breast Cancer Cells by Modulating AP-1 and NF-kappaB Signalling, Jiang, Grieb, Thyagarajan & Sliva, Int. J. Mol. Med. 2008; 21: 577-584. Ganoderma lucidum Inhibits Proliferation and Induces Apoptosis in Human Prostate cells PC-3, Jiang, Slivova, Valachovicova, et al., Int. J. Oncol. 2004; 24: 1093-1099.

OMEGA 3 OILS Modulation of Angiogenesis by Omega-3 Polyunsaturated Fatty Acids is Mediated by Cyclooxygenases, Szymczak, Murray & Petrovic,  Blood 2008; 111 (7): 3514-3521. N-3 Fatty Acids, Cancer and Cachexia: A Systematic Review of the Literature, Colomer, Moreno-Nogufeira, Garcia-Luna, et al., Br. J. Nutr. 2007; 975: 823-831. Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk. Fradet , Cheng, Casey &Witte,  Clin Cancer Res. 2009; 15 (7): 2559-2566. Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination with Omega-3 Fatty Acids, Swamy, Citineni, et al, Nutr. Cancer  2008; 60 Suppl. 1: 81-89. Omega 3 Fatty Acids: Biological Activity and Effects on Human Health, La Guardia, Giammanco, Di Majo, et al., Panminerva Med. 2005; 47 (4): 245-257. Effect of Eicosapentaenoic Acid, Protein and Amino Acids on Protein Synthesis and Degradation in Skeletal Muscle of Cachectic Mice, Smith, Greenberg & Tisdale,  Br. J. 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Impact of Post-operative Omega-3 Fatty Acid-supplemented Parenteral Nutrition on Clinical Outcomes and Immuno-modulations in Colorectal Cancer Patients, Liang, Wang, Ye, et al., World J. Gastroenterol. 2008; 14 (15): 2434-2439. High Omega-3 Fat Intake Improves Insulin Sensitivity and Reduces CRP and IL6, But Does Not Affect Other Endocrine Axes in Healthy Older Adults, Tsitouras, Gucciardo, Salbe, et al., Horm. Metab. Res. 2008; 40 (3): 199-205. Dietary Omega-3 Fatty Acids, Cyclo-oxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk, Fradet, Cheng, Casey & Witte, Clin, Cancer Res. 2009; 15 (7): 2559-2566. The Potential for Treatment with Dietary Long-chain Polyunsaturated n-3 Fatty Acids During Chemotherapy, Biondo, Brindley, Sawyer & Field, J. Nutr. Biochem. 2008; 1912: 787-796. Chemoprotective and Renal Protective Effects for Docosahexaenoic Acid (DHA): Implications of CRP and Lipid Peroxides, Elmesery, et al., Cell Div. 2009; 4 (1): 6. Omega-3 Fatty Acids Can Improve Radioresponse Modifying Tumor Interstitial Pressure, Blood Rheology and Membrane Peroxidability, Baronzio, Freitas, Griffini et al., Anticancer Res.  1994; 14 (3A): 1145-1154 Neuroblastoma Cell Death in Response to Docosahexaenoic acid: Sensitization to Chemotherapy and Arsenic-induced Oxidative Stress, Lindskog, Gleissman, Ponthan et al.,  Int. J. Cancer 2006; 118 (10): 2584-2593. Differential Sensitization of Cancer Cells to Doxorubicin by DHA: A Role for Lipoperoxidation, Maheo, Vibet, Steghens et al., Free Radic. Biol. Med. 2005; 39 (6): 742-751. Sensitization by Docosahexaenoic Acid (DHA) of Breast Cancer Cells to Anthracyclines Through Loss of Glutathione Peroxidase (GPx1) Response, Vibet, Goupille, Bougnoux, et al.,  Free Radic. Biol. Med. 2008; 44 (7): 1483-1491. Phase II Study of High-dose Fish Oil Capsules for Patients with Cancer-Related Cachexia, Burns, Halabi, Clamon, et al., Cancer 2004; 101: 370-378. The Effect of Dietary Omega-3 Polyunsaturated Fatty Acids on T-lymphocyte Subsets of Patients with Solid Tumors, Gogos, Ginopoulos, Zoumbos, et al., Cancer Detect. & Prev. 1995; 19 (5): 415-417. Enteral (Oral or Tube Administration) Nutritional Support and Eicosapentaenoic Acid in Patients with Cancer: A Systematic Review, Elia, Van Bokhorst-de van der Schueren, Garvey, et al., Int. J. Oncol. 2006; 28 (1): 5-23. Effect of a Protein and Energy Dense N-3 Fatty Acid Enriched Oral Supplement on Loss of Weight and Lean Tissue in Cancer Cachexia: A Randomised Double Blind Trial, Fearon, Von Meyenfeldt, Moses, et al., Gut 2003; 52 (10): 1479-1486. Modulation of Inflammation and Cytokine Production by Dietary (n-3) Fatty Acids, Blok, Katan & van der Meer,  J. Nutr. 1996; 126 (6): 1515-1533. Effect of Dietary Fish Oil on Development and Selected Functions of Murine Inflammatory Macrophages, Hubbard, Somers & Eriskson, J. Leukoc. Biol. 1991; 49: 592. 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PHYTOESTROGENS  & SOY Phytoestrogens and Antioxidants – Bits of Experimental Evidence, Mariani, Medscape General Medicine 01/24/2005 Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer, Piersen, Integr. Cancer Ther., 2003; 2 (2): 120-138.   Dietary Phytoestrogen Intake – Lignans, Isoflavones – and Breast Cancer Risk (Canada), Cotterchio, Boucher, Kreiger, et al.,  Cancer Causes & Control 2008; 193: 259-272. Flaxseed Oil Reduces the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen, Truan, Chen & Thompson,  Mol. Nutr. Food Res. 2010; 54: 1–8. Flaxseed Oil–Trastuzumab Interaction in Breast Cancer, Mason, Chen & Thompson, Food Chem Tox. 2010; doi:10.1016/j.fct.2010.05.052 Phytoestrogen Content of Foods Consumed in Canada, Including Isoflavones, Lignans, and Coumestan, Thompson, Boucher, Liu, et al., Nutr. Cancer, 2006; 54 (2): 184-201. 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