Minggu, 28 Desember 2014

Pomegranate Extract Inhibits Androgen-independent Prostate Cancer Growth Through a Nuclear Factor Kappa-B dependent Mechanism, Rettig, et al., Mol. Cancer Ther. 2008; 7 (9): 2662-2671.


Pomegranate Extract Inhibits Androgen-independent Prostate Cancer Growth Through a Nuclear Factor Kappa-B dependent Mechanism, Rettig, et al., Mol. Cancer Ther. 2008; 7 (9): 2662-2671.

In vitro Anti-proliferative, Apoptotic and Antioxidant Activities of Punicalagin, Ellagic Acid and a Total Pomegranate Tannin Extract are Enhanced in Combination with other Polyphenols as Found in Pomegranate Juice, Seeram, Adams, Henning, et al., J. Nutr. Biochem. 2005; 16 (6): 360-367.

Pomegranate Polyphenols  Down-regulate Expression of Androgen-synthesizing Genes in Human Prostate Cancer Cells Over-expressing the Androgen Receptor, Young, Hong, Seeram & Heber, J. Nutr. Biochem. 2008; 19 (12): 848-855.

Ellagic Acid Induces Apoptosis Through Inhibition of Nuclear Factor Kappa B in Pancreatic Cancer Cells, Edderkaoui, Odinokova, Ohno, et al., World J. Gastroenterol. 2008; 14 (23): 3672-3680.

Combined Inhibition of PDGF and VEGF Receptors by Ellagic Acid, a Dietary-derived Phenolic Compound, Labrecque, Lamy, Chapus, et al.,Carcinogenesis 2005; 26 (4): 821-826.

 In vitro Anti-proliferative Activities of Ellagic Acid, Losso, Bansode, Trappey, et al.,  J. Nutr. Biochem. 2004;15 (11): 672-678.

Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate, Falsaperla, Morgia, Tartarone, et al., Eur. Urol. 2005; 47 (4): 449-454.

 Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen Following Surgery or Radiation for Prostate Cancer, Pantuck, Leppert, Zomorodian, et al., Clin. Cancer Res. 2006; 12 (13): 4018-4026.

Berry Phytochemicals, Genomic Stability and Cancer: Evidence for Chemoprotection at Several Stages in the Carcinogenic Process, Duthie, Mol. Nutr. Food Res. 2007; 51 (6): 665-674.





Molecular Targets of Phytochemicals for Cancer Prevention, Lee, Bode & Dong, Rev. Cancer 2011; 11 (3): 211-218. 

Prostate Cancer Prevention by Nutritional Means to Alleviate Metabolic Syndrome, Barnard, Amer. J. Clin. Nutr. 2007; 863, s. 889-893.

Cancer Prevention – the Easy Choices, McKinney, Alive - Canadian Journal of Health & Nutrition, April 2005; 270: 48-53.
Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia, A Preliminary Report from a One-year Proof-of-Principle Study, Betuzzi, Brausi, Rizzi & Castagnetti, Cancer Res. 2006; 66 (2): 1234-1240.

Resveratrol: a Candidate Nutritional Substance for Prostate Cancer Prevention, Stewart, Artime & O’Brian,  J. Nutr. 2003; 133 (7 Suppl.): 2440S-2443S.

How to Prevent and Treat Cancer with Natural Medicine, Murray, Birdsall, Pizzorno & Reilly, Riverhead Books, 2002.

Antioxidant Vitamin and Mineral Supplementation May Help Prevent Prostate Cancer Meyer, et al., Int. J. Cancer, 2005; 116: 182-186.

Herbicides and Non-Hodgkins Lymphoma: New Evidence from a Study of Saskatchewan Farmers, Blair, J. Int. Cancer Inst. 1990; 85: 544-545.

Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes, Searles Nielsen, McKean-Cowdin, Federico, et al., Envir. Health Perspect. 118:144–149 (2010).

Glutathione Treatment of Hepatocellular Carcinoma, Dalhoff, et al., Liver 1992; 12: 341-343.

EcoCancers: Do Environmental Factors Underlie a Breast Cancer Epidemic?, Raloff, Sci. News 1993; 144: 10-13.

Paraben Esters: Review of Recent Studies of Endocrine Toxicity, Absorption, Esterase and Human Exposure, and Discussion of Potential Human Health Risks, Darbe & Harvey, J. Appl. Toxicol. 2008; 285: 561-578.

Coffee Consumption and the Risk of Oral, Pharngeal and Esophageal Cancers in Japan: The Miyagi Cohort Study, Naganuma, Kuriyama, Kakizaki, et al., Am. J. Epidemiol. 2008; 16812: 1425-1432.

Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-metabolizing Enzymes, and Colorectal Cancer Risk, Cotterchio, Boucher, Manno, et al., Cancer Epidemiol. Biomarkers & Prev. 2008; 1711: 3098-3107.




Suppression of Insulin-like Growth Factor Signalling Pathway and Collagen Expression in Keloid-derived Fibroblasts by Quercetin: Its Therapeutic Potential Use in the Treatment and/or Prevention of Keloids, Phan, See, Tran, et al., Br. J. Dermatol. 2003; 148 (3): 544-552.

Differential Responses of Skin Cancer Chemoprotective Agents Silibinin, Quercitin and Epigallocatechin 3-Gallate on Mitogenic Signalling and Cell Cycle Regulators in Human Epidermoid carcinoma A431 Cells, Bhatia, Agarwal & Agarwal,  Nutr. & Cancer.  2001; 39 (2); 292-299.

Role of Mitochondria in Quercitin-enhanced Chemotherapeutic Response in Human Non-Small Cell Lung Carcinoma H-520 Cells,  Kuhar, Sen & Singh,  Anticancer Res. 2006; 26 (2A): 1297-1303.

Inhibition of Lung Cancer Cell Growth by Quercitin Glucoronides via G2/M Arrest and Induction of Apoptosis, Yang, Hsia, Kuo, et al., Drug Metab. Dispos. 2006, 34 (2): 296-304.

Induction of Cell-cycle Arrest and Apoptosis in Human Breast cancer Cells by Quercitin, Choi, Kim, Lee, et al., Int. J. Oncol. 2001; 19 (4): 837-844.

Antioxidants and Cancer III – Quercitin, Lamson & Brignall, Alt. Med. Rev. 2000; Vol. 5 No. 6: 196-208.

Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines, Ramos & Aller, Biochem Pharmacol. 2008;75 (10):1912-1923.

Apple Phytochemicals and Their Health Benefits, Boyer & Liu, Nutr. J. 2004; 3 (5)

Enhanced Bioavailability of Tamoxifen after Oral Administration of Tamoxifen with Quercitin in Rats, Shin, Choi & Li, Int. J. Pharm. 2006; 313 (1-2): 144-149.

Inhibition of P-Glycoprotein by Flavonoid Derivatives (Quercitin and Morin) in Adriamycin-Resistant Human Myelogenous Leukemia (K562/ADM) Cells, Ohtani, Koyabu, Juichi, et al., Cancer Lett. 2002; 177 (1): 89-93.

Effects of Quercitin on the Cell Growth and the Intracellular Accumulation and Retention of Adriamycin, Asaum, Matsuzaki, Kawasak, et al., Anticancer Res. 200; 20 (4): 2477-2483.

Quercitin Potentiates the Effect of Adriamycin in a Multi-Drug-Resistant MCF-7 Human Breast Cancer Cell Line: P-Glycoprotein as a Possible Target, Scambia, Ranelletti, Panici, et al., Cancer Chemother. Pharmacol. 1994; 34 (6): 459-464.

Suppression of Multi-Drug Resistance Via Inhibition of Heat Shock Factor by Quercitin in MDR Cells, Kim, Yeo, Lim, et al., Exp. Mol. Med. 1998; 30 (2): 87-92.

Synergistic Antiproliferative Activity of Quercitin and Cisplatin on Ovarian Cancer Cell Growth, Scambia, Ranelletti, Benedetti, et al., Anticancer Drugs 1990; 1 (1): 45-48.

Drug Resistance Against Gemcitabine and Topotecan Mediated by Constituitive HSP-70 Over-expression in vitro: Implication of Quercitin as a Sensitiser in Chemotherapy, Sluitz, Karlseder, Temfer, et al., Br. J. Cancer 1996; 74 (2): 172-177.

Low-concentrations of Quercitin and Ellagic Acid Synergistically Influence Proliferation, Cytotoxicity and Apoptosis in MOLT-4 Human Leukemia Cells, Mertens-Talcott, Talcott & Percival, J. Nutr. 2003; 133 (8): 2669-2674.

Spontaneous mitochondrial membrane potential change during apoptotic induction by quercitin in K562 and K562/adr cells, Kothan, Dechsupa, Leger, et al., Can. J. Physiol. Pharmacol. 2004, 82 (12): 1084-1090.

Food-derived Polyphenols Inhibit Pancreatic Cancer Growth Through Mitochondrial Cytochrome C Release and Apoptosis, Suolinna, Buschbaum & Racker, Cancer Res. 1975; 35 (7): 1865-1872.

Quercitin Induces Necrosis and Apoptosis in SCC-9 Oral Cancer Cells, Haghiac & Walle, Nutr. Cancer 2005; 53 (2):220-231.

Selective Aromatase Inhibition for Patients with Androgen-independent Prostate Carcinoma, Smith, Kaufman, George, et al., Cancer  2002; 95 (9): 1864-1868.

Absorption and Disposition Kinetics of the Dietary Antioxidant Quercitin in Man, Hollman, vd Gaag, Mengelers, et al., Free Rad Biol Med  1996; 21 (5): 703-707.

Quercetin Potentiates the Effect of Adriamycin in a Multidrug-resistant MCF-7 Human Breast-Cancer Cell Line: P-glycoprotein as a Possible Target, Scambia, Ranelletti, Panici, et al.  Cancer Chemother.  Pharmacol.  1994; 34 (6): 459-464.

Flavonoids: a Class of Modulators with Bifunctional Interactions at Vicinal ATP- and Steroid-binding Sites on Mouse P-glycoprotein, Conseil,  Baubichon-Cortay, Dayan, et al., Proc. Nat. Acad. Sci. 1998; 95 (17): 9831-9836.

Absorption of Dietary Quercetin Glycosides and Quercetin in Healthy Ileostomy Volunteers, Hollman, de Vries, van Leeuwen, Mengelers,& Katan, (1995). Amer. J. Clin. Nutr. 1995; 62: 1276–1282.

The Synergistic Reversal Effect of Multidrug Resistance by Quercetin and Hyperthermia in Doxorubicin-Resistant Human Myelogenous Leukemia Cells, Shen, Zhang, Wu & Zhu, Int. J. Hyperthermia  2008 ;24 (2): 151-159.

Apoptosis of Murine Melanoma B16-BL6 Cells Induced by Quercetin Targeting Mitochondria, Inhibiting Expression of PKC-alpha and Translocating PKC-delta, Zhang, Chen, Xia & Xu,  Cancer Chemother. Pharmacol. 2005; 55 (3): 251-262.

Quercetin-Induced Ubiquination and Down-Regulation of Her2/neu, Jeong, An, Kwon, et al., J. Cell Biochem. 2008; 105: 585-595.




Timing is Everything in Combined Antiangiogenic / Radiation Therapy, Jain, Cancer Cell  2004; 6: 553-563.

Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: a Double-blinded Randomized Study, Lin, Que, Lin, et al., Int. J. Radiat. Oncol. Biol. Phys. 2008; 702: 368-373.

Antioxidants and Radiation Therapy, J. Nutr.  Borek, 2004; 134: S3207-S-3209.

Effects of Rhubarb Extract on Radiation Induced Lung Toxicity Via Decreasing Transforming Growth Factor Beta-1 and Interleukin-6 in Lung Cancer Patients Treated with Radiotherapy, Yu, Liu, Cheng, et al., Lung Cancer 2008; 592: 219-226.

ARCON (accelerated radiotherapy with carbogen and nicotinamide): a Novel Biology-based Approach in Radiotherapy  Kanders, Bussink & van der Kogel, Lancet Oncol. 2002; 3 (12): 728-737.

Radiosensitization by Nicotinamide in vivo: A Greater Enhancement of Tumor Damage Compared to that of Normal Tissue, Horsman, Chaplin & Brown, Rad. Res. 1987; 109: 479-489.

Mechanism of Action of the Selective Tumor Radio-Sensitizer Nicotinamide, Horsman, Brown, et al,  Int. J. Rad. Onc. Biophys. 1988; 15: 685-690.

Nicotinamide and Other Benzamide Analogs as Agents for Overcoming Hypoxic Cell Radiation Resistance in Tumors. A Review, Horsman, Acta Oncol. 1995; 34 (5): 571-587.

Do Antioxidants Interfere with Radiation Therapy for Cancer?, Moss, Integr. Cancer Ther. 2007, 6 (3): 281-292.

Acute Adverse Effects of Radiation Therapy and Local Recurrence in Relation to Dietary and Plasma Beta Carotene and Alpha Tocopherol in Head and Neck Cancer Patients, Meyer, Bairati, Jobin, et al., Nutr. Cancer  2007; 59 (1): 29-35.

Dietary Counselling Benefits Patients Undergoing Radiotherapy, Ravasco. et al., J. Clin. Oncol. 2005; 23: 1348-1349, 1431-1438.

Effect of Concomitant Naturopathic Therapies on Clinical Tumor Response to External Beam Radiation Therapy for Prostate Cancer (Abstract), Birdsall, Alschuler, Martin, et al., Soc. Integr. Oncol.  Nov. 2006, Boston, Mass.

Effect of Complementary Alternative Medical (CAM) Therapy on Tumor Response in Prostate Cancer Patients Treated with Radiation Therapy, Cain, Flynn, Kelly, et al., J. Clin. Oncol. 2007; 25: 15585.

Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation, Saha & Choy, Prog Exp. Tumor Res. 2003; 37: 193-209.

Long-term Use of Cellular Phones and Brain Tumours: Increased Risk Associated with Use for >=
10 Years, Hardell, Carlberg, Soderqvist, et al., Occup. Envir. Med. 2007; 64 (9): 626-632.

Oral Vitamin A Therapy for a Patient with a Severely Symptomatic Post-Radiation Anal Ulceration, Levitsky, Hong, Jani & Ehrenpreis, Dis. Colon Rectum 2003; 46 (5): 679- 682.

Phase I Study of Concurrent Radiotherapy with TS-1 and Vitamin A (TAR Therapy) for Head and Neck Cancer, Nakashima, Kuramoti, Yamamoto, et al., Gan To Kagaku Ryoho  2005; 32 (6): 803-807.

Sensitization of Cervical Cancer Cell Lines to Low-dose Radiation by Retinoic Acid Does Not Require Functional p53, Tillmanns, Kamelle, Guruswamy, et al., Gynecol Oncol 2005; 97 (1): 142-150.

Supplemental Vitamin A Prevents the Acute Radiation-induced Defect in Wound Healing, Levenson, Gruber, Rettura, et al., Ann. Surg. 1984; 200 (4): 494-512.

Protective Effect of Vitamin A on Acute Radiation Injury in the Small Intestine, BeyzadeoÄŸlu, Balkan, Demiriz, et al., Radiat. Med. 1997; 15 (1): 1-5.

A New Electromagnetic Exposure Metric: High Frequency Voltage Transients Associated with Increased Cancer Incidence in Teachers in a California School, Milham & Morgan, Am. J. Ind. Med. 2008; 51(8):579-586.

Arachidonic Acid Metabolites Mediate the Radiation-induced Increase in Glomerular Albumin Permeability, Sharma, McCarthy, Sharma, et al., Exp. Biol. Med. 2006; 231: 99-106. 

Enhanced Radiosensitivity of Rat Autochthonous Mammary Tumors by Dietary Docosahexaenoic Acid, Colas, Paon, Denis, et al., Int. J. Cancer 2004; 109 (3): 449-454.

[Omega-3 Fatty Acid-containing Diet (Racol) Reduces Toxicity of Chemo-radiation Therapy for Patients with Esophageal Cancer], Minami, Miyata, Doki, et al., Gan To Kagaku Ryoho 2008; 35 (3): 437-440.

Aloe vera for Preventing Radiation-induced Skin Reactions: A Systematic Literature Review, Richardson, Smith, McIntyre, et al., Clin. Oncol (R. Coll. Radiol). 2005; 17 (6): 478-484.

Prevention of Chemotherapy and Radiation Toxicity with Glutamine, Savarese, Savy, Vahdat, et al., Cancer Treat. Rev. 2003; 29 (6): 501-513.

Successful and Sustained Treatment of Chronic Radiation Proctitis with Antioxidant Vitamins E and C,  Kennedy, Bruninga, Mutlu, et. al., Am. J.Gastroenterol. 2001; 96 (4): 1080-1084.

Protective effects of Berberine on Radiation-induced Lung Injury via Intercellular Adhesion Molecule-1 and Transforming Growth Factor beta-1 in Patients with Lung Cancer, Liu, Yu, Zhang, et al., Eur. J. Cancer 2008; 44 (16): 2425-2432.

D-alpha-tocopherol Succinate (Vitamin E) Enhances Radiation-induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells, Kumar, Jha, Cole, et al., J. Amer. Coll Nutr. 2002; 21 (4): 339-343.

Can the Therapeutic Gain of Radiotherapy Be Increased by Concurrent Administration of Asian Botanicals?, Sagar, Integr. Cancer Ther. 2010; 9 (1): 5-13.   Dr. Lawenda’s response pp. 14-15.

Curcumin – a New Radiosensitizer of Squamous Cell Carcinoma Cells, Khafif, et al., Otolarngol. Head Neck Surg., 2005; 132: 317-321.

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to ɤ-Radiation by Targeting
Nuclear Factor-B–Regulated Gene Products, Kunnumakkara1, Diagaradjane, Guha, et al., Clin.Cancer Res.  2008;14: 2128-2136.

The Chemopreventative Agent Curcumin is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased ROS production and Overactivation of the MAPK Pathway, Javvadi, Segan, Tuttle, et al., Mol. Pharmacol.  2008 Feb. 5  Epub ahead of print, PMID# 18252805.

Curcumin Induces Chemo/Radio-Sensitization in Ovarian Cells and Curcumin Nanoparticles Inhibit Ovarian Cancer Cell Growth, Yallapu, Maher, Sundram, et al., J. Ovar. Res. 2010; 3: 11.

Berberine Inhibits Acute Radiation Intestinal Syndrome in Human with Abdomen Radiotherapy, Li, Wang, Hu, et al., Med. Oncol. 2010; 27 (3): 919-925.

Randomized Phase II Trial of High-dose Melatonin and Radiation Therapy for RPA Class 2 Patients with Brain Metastases (RTOG 0119),   Berk, Berkey, Rich et al., Int. J. Radiat. Oncol. Biol. Phys. 2007 Jul 1;68(3):852-7. Epub 2007 Apr 6.

Oral Glutamine to Alleviate Radiation-Induced Oral Mucositis: A Pilot Randomized Trial, Huang, Leung, Wang, et al., Int. J. Radiat. Oncol. Biol. Phys. 2000; 46 (3): 535–539.

Prevention of Chemotherapy and Radiation Toxicity with Glutamine, Savarese, Savy, Vahdat, et al., Cancer Treat. Rev.  2003: 29 (6): 501-513.
Protective Effects of Berberine on Radiation-Induced Lung Injury via Intercellular Adhesion Molecular-1 and Transforming Growth Factor-beta-1 in Patients with Lung Cancer, Liu, Yu, Zhang, et al., buy cheap oem Eur. J. Cancer 2008; 44 (16): 2425-2432.  Epub 2008 Sep 11.
Interferon-Gamma Links Ultraviolet Radiation to Melanomagenesis in Mice, Zaidi, Davis, Noonan, et al., Nature 2010, DOI: 10.1038/nature09666.
Soy Isoflavones in Conjunction with Radiation Therapy in Patients with Prostate Cancer. Ahmad, Forman, Sarkar, et al. Nutr. Cancer  2010; 627: 996-1000.



Tumour Stem Cells: Rooting Out Resistance, Rich, et al., Nat. Rev. Cancer 2006; 6 (12): 904-905. Medscape article 550020

The Paradox of Response and Survival in Cancer Therapeutics, Huff, Matsui, Smith & Jones, Blood 2006; 107: 4321-434.

Will Cancer Stem Cell Provide New Therapeutic Targets?-  Review, Behbod & Rosen, Carcinogenesis 2004;
26 (4): 703-711.

Cancer Stem cells: Are We Missing the Target? – Commentary, Jones, Matsui & Smith, J. Natl. Cancer Inst.
2004; 96 (8): 583-585.
On Mammary Stem Cells, Woodward, Chen, Behbod & Rosen, J. Cell Sci. 2005; 118: 3585-3594.
Cancer Stem Cells - Review, Jordan, Guzman & Noble, NEJM 2006; 355 (12): 1253-1261.

Bone Marrow Derived Cells & Cancer – An Opportunity for Improved Therapy,  Houghton, Nat. Clin. Pract. Oncol.  2007; 4 (1): 2-3.  Medscape article 551187

The Lymphovascular Embolus of Inflammatory Breast Cancer Expresses a Stem Cell-like Phenotype, Xiao, Ye, Yearsley, et al., Amer. J. Pathol. 2008; 173 (2): 561-574.

Insights into Breast Cancer Heterogenicity – Stem Cells, Skinner, Nat. Rev. Cancer 2010; 10 (3): 163.

Leukaemia Stem Cells & the Evolution of Cancer Stem Cell Research, Huntley & Gilliand, Nat. Rev. Cancer  2005; 5: 311-321.

Human Pancreatic Cancer Stem Cells Identified, Simenone, et al., Cancer Res. 2007  Medscape article 551581

Brain Tumor Cells Lurk in Perivascular Niches, Gilbertson, Cancer Cell  2007; 11: 3-5, 69-82.   Medscape article 551315.

Bone Morphogenetic Proteins Inhibit the Tumorigenic Potential of Human Brain Tumor-initiating Cells, Piccirillo & Vescovi, Nature 2006; 444: 761-765.   

Brain Tumour Stem Cells, Vescovi, Galli, and Reynolds, Nat. Rev. Cancer 2006; 6 (1): 425-436.

Targeting Breast Stem Cells with the Cancer Preventive Compounds Curcumin and Piperine, Kakarala, Brenner,    Korkaya, et al., Breast  Cancer Res. Treat.  2009 [Epub ahead of print]  PMID: 19898931

Relation of Tumor Associated Macrophages and Mast Cells of Tumor Interstitum and Angiogenesis in Non-small Cell Lung Cancer, Zou & Hu, Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007; 32 (6):1037-1041.

Association of Macrophages, Mast Cells and Eosinophil Leukocytes with Angiogenesis and Tumor Stage in Non-small Cell Lung Carcinomas (NSCLC), TataroÄŸlu, Kargi, Ozka, et al., Lung Cancer  2004; 43 (1): 47-54.
Inflammatory Cell Infiltration of Tumors: Jekyll or Hyde, Talmadge, Donkor & Scholar, Cancer Metastasis Rev. 2007; 26 (3-4): 373-400.
Human Macrophages Promote the Motility and Invasiveness of Osteopontin-knockdown Tumor Cells, Cheng, Huo, Kuang, et al., Cancer Res. 2007; 67( 11): 5141-5147.

Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion,  Clark, Hingorani , Mick, et al.,   Cancer Res. 2007;67 (19): 9518-9527.
Increased Expression of Human Macrophage Metalloelastase (MMP-12) is Associated with the Invasion of Endometrial Adenocarcinoma, Yang, Dong, Zhao,et al.,  Pathol Res Pract. 2007; 203 (7): 499-505. Epub 2007 Jun 14.
Role of Tumor-associated Macrophages in Tumor Progression and Invasion, Mantovani, Schioppa, Porta, et al.,  Cancer Metastasis Rev. 2006;25( 3): 315-322.
Co-opting Macrophage Traits in Cancer Progression: A Consequence of Tumor Cell Fusion? Pawelek, Chakraborty, Lazova, etr al., Contrib Microbiol. 2006; 13: 138-155.
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis, Condeelis & PollardCell 2006;124 (2): 263-266.
Prostate Cancer: Genes, Environment, Immunity and the Use of Immunotherapy, Karan, Thrasher & Lubaroff, Prostate Cancer Prostatic Dis.  2008; 11 (3): 230-236.

ER Alpha  Status of Disseminated Tumor Cells in Bone Marrow of Primary Breast Cancer Patients, Fehm, Krawczyk, Solomayer, et al.,  Breast Cancer Res.  2008; 0 (5): R76.

Resistance of Cancer Cells to Immune Recognition and Killing, Lipinski & Egyud, Med. Hypoth. 2000; 54 (3): 456-460.
Molecular Biology of Macrophage Activation: A Pathway Whereby Psychosocial Factors Can Potentially Affect Health, Adams, Psychosomat. Med. 1994; 56: 316-327.
Disregulation in TH1 and TH2 Subsets of CD4+ T Cells in Peripheral Blood of Colorectal Cancer Patients and Involvement in Cancer Establishment and Progression, Pellegrini,  Berghella, Del Beato, et al., Cancer Immunol. Immunother. 1996; 42 (1): 1-8.
Th1/Th2 balance: The Hypothesis, Its Limitations, and Implications for Health and Disease, Kidd, Altern. Med. Rev. 2003; 8(3):223-46
Effect of Major Dietary Modifications on the Immune System in Patients with Breast Cancer, Garritson, Nikaein, Peters, et al., Cancer Practice  1995; 3 (4): 239-246.
In vivo Effect of Ascorbic Acid on Enhancement of Human Natural Killer Cell Activity,  Vojdani & Ghoneum,  Nutr. Res.1993; 13: 753-754.
Enhancement of Human Natural Killer Cytotoxic Activity by Vitamin C in Pure and Augmented Formulations, Vojdani & Namatalla, J. Nutr. Environ. Med. 1997; 7 (3): 187-195.
Cancer-expanded Myeloid-derived Suppressor Cells Induce Anergy of NK Cells Through Membrane-bound TGF-beta 1, Li, Han, Guo, et al., J. Immunol. 2009; 182 (1): 240-249.

Signaling Mechanism(s) of Reactive Oxygen Species in Epithelial-Mesenchymal Transition Reminiscent of Cancer Stem Cells in Tumor Progression, Wang, Li & Sarkar, Curr. Stem Cell Res. Ther. 2010; 5 (1): 1-7.





Insulin and Cancer,  Boyd,  Integr. Cancer. Ther., 2003; 2 (4): 315-329.

Insulin-like Growth Factor 1 Tied to Prostate Cancer Risk, Douglas, Medscape 487836 8/25/04.

Insulin-Like Growth Factor I Receptor Promotes Gastric Cancer Adachi. et al., Gut 2005; 54: 591-600.

Diabetes, High Glucose Levels Linked to Cancer in Korean Study, Jee, et al., JAMA  2005; 194-202 and editorial p. 235-236.

Diabetes Triples Risk of Liver Cancer, El-Serag, et al, Gut, 2005; 54: 533-539.

Elevated IGF-1 Linked to Raised Risk of Cancer in Premenopausal Women, Shi, et al, Int. J. Cancer  2004; 111: 418-423.

High Dietary Glycemic Load May Increase Colorectal Cancer Risk in Women, Higginbotham, et al,  J. Natl. Cancer Inst. 2004; 96: 229-233.

High Dietary Glycemic Load and Insulin Resistance Combine to Increase Pancreatic Cancer Risk,  Michaud, et al.,  J. Natl. Cancer Inst. 2002; 94: 1293-1300.

Controlling Hyperglycemia as an Adjunct to Cancer Therapy, Krone & Ely, Integr. Cancer Ther.  2005; 4 (1): 25-31.

Fasting Insulin and Outcome in Early-Stage Breast Cancer-  Results of a Prospective Cohort Study,  Goodwin, et al, J. Clin. Oncol., 2002; 20: 42-51.

Glycemic Index, Glycemic Load and Thyroid Cancer Risk,  Randi, Ferraroni, Talamini, et al., Annals of Oncol.  2008; 192: 380-383.

Green Tea Polyphenols Inhibit IGF-1 Signalling in Prostate Cancer Model, Mukhtar, et al., Cancer Res.  2004; 64: 8715-8722.

Postprandial Hyperinsulinemia Accelerates Growth of Hepatocellular Carcinoma, Kawata, et al., Gut  2002; 51: 100-104.

Insulin-like Growth Factor -1 Activates Gene Transcription Programs Strongly Associated with Poor Breast Cancer Prognosis,  Chreighton, Casa, Lazard, et al., J Clin Oncol  2008; 26 (25): 4078-4085.

Insulin, Insulin-like Growth Factors and Colon Cancer: A Review of the Evidence, Giovannucci, J Nutr
2001; 131 (Suppl. 11): s3109-3120.

Glycemic Index, Glycemic Load, and Cancer Risk: A Meta-analysis, Gnagnarella, Gandini, La Vecchia, & Maisonneuve,  Amer. J. Clin. Nutr.  2008; 87 (6): 1793-1801.

Up-regulation of IGF Binding Protein-1 as an Anti-carcinogenic Strategy: Relevance to Caloric Restriction, Exercise, and Insulin Sensitivity, McCarty, Medical Hypotheses 1997; 48 (4): 297-308.

The Insulin-like Growth Factor System as a Treatment Target in Breast Cancer, Yee,  Sem. Oncol. 2002; 29 (3 Suppl 11): 86-95.

Cross-talk Among Estrogen Receptor, Epidermal Growth Factor, and Insulin-like Growth Factor Signaling in Breast Cancer, Lee, Cui & Oesterreich, Clin. Cancer Res. 2001; 7 (12 Suppl): 4429s-4435s.

Tyrosine Kinase Signalling in Breast Cancer: Insulin-like Growth Factors and Their Receptors in Breast Cancer, Zhang & Yee, Breast Cancer Res. 2000; 2 (3): 170-175.

Insulin-like Growth Factors and Cancer, Furstenberger & Senn, Lancet Oncol. 2002; 3 (5): 298-302.

Insulin-Like Growth Factor (IGF) Family and Prostate Cancer, Gennigens, Menetrier-Caux & Droz,  Crit. Rev. Oncol. Hematol. 2006; 58 (2): 124-145.

Activation of Estrogen Receptor-mediated Gene Transcription by IGF-I in Human Breast Cancer Cells,  Lee, Weng, Jackson & Yee, J. Endocrinol. 1997; 152 (1): 39-47.

Vitamin D Analogue EB1089-induced Prostate Regression is Associated with Increased Gene Expression of Insulin-like Growth Factor Binding Proteins, Nickerson T. Huynh H.   J. Endocrinol. 1999; 160 (2): 223-229.

Pharmacological Modulation of IGF Serum Concentrations as a Therapeutic Approach to Control the Growth of Malignant Breast Tumors, Singer, Hudelist, Schreiber & Kubista, Drugs Today (Barc). 2003; 39 (2): 115-125.

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